反应详情

温度

27.5 °C

Crude eprosartan free base (50 gm, HPLC purity: 98.2%) is added to acetic acid (200 ml) under stirring at 25-30° C., the contents are heated to 80° C., to the resulting mass is added activated carbon (5 gm) and then stirred for 1 hour. The mass is filtered through a hyflow bed and the bed washed with hot acetic acid (50 ml). The filtrate is cooled to 25-30° C., methylene chloride (750 ml) is added drop wise to the mass and then stirred for 24 hours at 25-30° C. The mass is cooled to 0-5° C. and then stirred for 2 hours. The material is filtered, washed with methylene chloride (43 ml) and then dried to give 30 gm of pure eprosartan acetate (HPLC purity: 99.82%).

1. temperaturethe contents are heated to 80° C., to the resulting mass
2. additionis added activated carbon (5 gm)
3. stirringstirred for 1 hour
4. filtrationThe mass is filtered through a hyflow bed
5. washthe bed washed with hot acetic acid (50 ml)
6. temperatureThe filtrate is cooled to 25-30° C.
7. additionmethylene chloride (750 ml) is added drop wise to the mass
8. stirringstirred for 24 hours at 25-30° C
9. temperatureThe mass is cooled to 0-5° C.
10. stirringstirred for 2 hours
11. filtrationThe material is filtered
12. washwashed with methylene chloride (43 ml)
13. customdried