Dapagliflozin → HCID 131728579, compound

HRID 1808711Notes

Reaction equation

HRID 1808711 reaction equation
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:8][CH:9]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]>>[CH3:1][CH2:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:6][CH:5]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]

Participants

3

Reactant 2

HCID 9887712DapagliflozinHCID 56841155HCID 56841155, compound

Product 1

HCID 131728579HCID 131728579, compound

Procedure

Tablets containing the SGLT2 inhibitor dapagliflozin or dapagliflozin propylene glycol hydrate were prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9) as described below.

Workup

  1. customwere prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9)

Sources & evidence

ORD record
ord-e25323b77c094879a7e074300e9ab4b9
Source dataset
uspto-grants-2013_01
Patent number
US08361972B2

Reaction notes

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