Dichloromethane → HCID 70664378, compound

Participants

Reaction Conditions

Reaction Steps

To a dichloromethane (200 mL) and diethyl ether (200 mL) solution of (S)-3-hydroxypyrrolidine (19.8 mL, 244 mmol) and triethylamine (45.0 mL, 323 mmol) at 0° C. was added tert-butyl isocyanate (28.0 mL, 245 mmol). The reaction mixture was stirred for 1 hour at 0° C., filtered, and concentrated in vacuo to afford the title compound as a white solid. This crude product was used in the subsequent step without further purification. 1H NMR (500 MHz, CDCl3) δ 4.50-4.45 (m, 1H), 3.50-3.34 (m, 4H), 2.08-1.93 (m, 2H), 1.35 (s, 9H); LC-MS: m/z 187.3 (M+H).

Provenance & Evidence