Sodium borohydride → HCID 70968283, compound

HRID 1808752Notes

Reaction equation

[BH4-].[Na+].[N:3]1([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:13]=[C:14]([CH:37]=[CH:38][CH:39]=2)[CH:15]=[C:16]2[CH2:21][C@H:20]3[C@H:22]4[C@H:32]([CH2:33][CH2:34][C@:18]3([CH3:19])[C:17]2=[O:36])[C@:30]2([CH3:31])[C:25]([CH2:26][C@@H:27]([OH:35])[CH2:28][CH2:29]2)=[CH:24][CH2:23]4)[CH:7]=[CH:6][N:5]=[CH:4]1>>[N:3]1([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:13]=[C:14]([CH:37]=[CH:38][CH:39]=2)[CH:15]=[C:16]2[CH2:21][C@H:20]3[C@H:22]4[C@H:32]([CH2:33][CH2:34][C@:18]3([CH3:19])[C@H:17]2[OH:36])[C@:30]2([CH3:31])[C:25]([CH2:26][C@@H:27]([OH:35])[CH2:28][CH2:29]2)=[CH:24][CH2:23]4)[CH:7]=[CH:6][N:5]=[CH:4]1

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 68937089HCID 68937089, compound

Product 1

HCID 70968283HCID 70968283, compound

Procedure

16-[3-{3-(IMIDAZOL-1-YL)PROPOXY}BENZYLIDENE]-5-ANDROSTENE-3β,17β-DIOL (20) (DPJ-RG-1310) was prepared by sodium borohydride reduction of 18 using a method as described for 14

Sources & evidence

ORD record: ord-07799f4384914aae9f0596601556c9a4
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08361996B2

Reaction notes

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