反应详情

A mixture of 5-androstene-3β,17β-diol (1 g, 3.44 mmol), acetic anhydride (2 Ml) and dry pyridine (4 Ml) was heated in a steam bath for 2 h, and poured into iced water. The precipitate was filtered, washed with water, dried and crystallized in methanol to afford the product 5-androstene-3β,17β-diol diacetate (1 g, 81.3%), mp 163-165° C. [Singh H., et al Indian J. Chem. 1969, 7, 1084-1087].

1. temperaturewas heated in a steam bath for 2 h
2. filtrationThe precipitate was filtered
3. washwashed with water
4. customdried
5. customcrystallized in methanol