HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-Oximino-5-androstene-3beta,17beta-diol Diacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl diacetate | HCID 9886600 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 7-Oximino-5-androstene-3beta,17beta-diol Diacetate | HCID 86761753 | — |
Reaction Steps
7-Oxo-5-androstene-3β,17β-diol diacetate (1 g, 2.57 mmol) and hydroxylamine hydrochloride (0.5 g) were taken in dry pyridine (8 Ml) and heated in a steam bath for 2 h. The reaction mixture was poured into water and precipitate obtained was filtered, washed with water and dried. The crude product on crystallization from methanol afforded pure oxime 7-oximino-5-androstene-3β,17β-diol diacetate (0.85 g, 86.54%), mp 236-238° C. (lit 226° C.) [Singh H., et al Indian J. Chem. 1969, 7, 1084-1087].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08361996B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-5dafd30003e84c71aab2a5a8b26d3aed |
| Source note | uspto-grants-2013_01 |