Imidazole → 7-[O-{3-(imidazol-1-yl)propyl}oximino]-5-androstene-3beta,17beta-diol diacetate

Participants

Reaction Steps

A mixture of 7-[O-(3-chloropropyl)oximino]-5-androstene-3β,17β-diol diacetate (23) (1 g, 2.08 mmol) and powdered imidazole (1.5 g) was fused at 110-120° C. for 5 h. The completion of reaction was monitored by TLC. The reaction was quenched with iced water to afford a the product 7-[O-{3-(imidazol-1-yl)propyl}oximino]-5-androstene-3β,17β-diol diacetate (24)

Provenance & Evidence