HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 2-phenyl-benzoxazole-6-carboxylate | HCID 10586965 | — |
| Reactant | 2-Phenyl-1,3-benzoxazole-6-carboxylic acid | HCID 10900714 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzoyl chloride | HCID 7412 | — |
Reaction Steps
2-Phenyl-benzooxazole-6-carboxylic acid, 1v. A mixture of methyl 2-phenyl-benzooxazole-6-carboxylate 1u (0.37 g, 1.46 mmol) and LiOH (0.10 g, 4.2 mmol) in THF (4 mL), MeOH (4 mL), and H2O (4 mL) was stirred at room temperature for 6 h. Aqueous 1N HCl solution was added to the mixture to adjust pH to 3-4. The resulting mixture was extracted with EtOAc (2×). The organic solution was washed with aq. NaCl, dried over Na2SO4 and concentrated to give 1t (0.34 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362000B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-430d1e141d334d48b3e160c4c618e5fc |
| Source note | uspto-grants-2013_01 |