2,3-Dihydroxybutanedioic Acid → HCID 67771938, compound

HRID 1808826Notes

Reaction equation

HRID 1808826 reaction equation
[C:1]([OH:10])(=[O:9])[CH:2]([CH:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:31]=[CH:30][C:15]([C:16]([N:18]([C@@H:20]([CH2:27][CH2:28][CH3:29])[CH2:21][N:22]2[CH2:25][CH:24]([OH:26])[CH2:23]2)[CH3:19])=[O:17])=[CH:14][CH:13]=1>CO>[C:6]([CH:4]([CH:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([C:16]([N:18]([C@@H:20]([CH2:27][CH2:28][CH3:29])[CH2:21][N:22]2[CH2:25][CH:24]([OH:26])[CH2:23]2)[CH3:19])=[O:17])=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 57345459HCID 57345459, compound

Product 1

HCID 67771938HCID 67771938, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of tartaric acid in MeOH (0.1 M, 0.48 ml) was added to (S)-4-Chloro-N-(1-(3-hydroxyazetidin-1-yl)pentan-2-yl)-N-methylbenzamide (Example 8.2A) (15 mg, 48 μmol) and allowed to evaporate. The product was dissolved in EtOAc (1 mL) and allowed to evaporate until dry.

Workup

  1. customto evaporate
  2. dissolutionThe product was dissolved in EtOAc (1 mL)
  3. customto evaporate
  4. customuntil dry

Sources & evidence

ORD record
ord-9112710586cb4aa3a17a8e12f3bee2d5
Source dataset
uspto-grants-2013_01
Patent number
US08361998B2

Reaction notes

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