Carbon Tetrachloride → HCID 66692180, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 4-(6-aminopyridin-2-yl)piperazine-1-carboxylate (320 mg, 1.150 mmol) and NCS (307 mg, 2.299 mmol) in Carbon tetrachloride (10 mL)/CH2Cl2 (5.00 mL) was refluxed at 40° C. for 2 h. Purification on silicon gel column with DCM, then 2% EtOAc in DCM gave tert-butyl 4-(6-amino-3,5-dichloropyridin-2-yl)piperazine-1-carboxylate (110 mg, 0.305 mmol, 26.5% yield). 1H-NMR (CDCl3, 500 MHz): δ 7.39 (1H, s), 4.71 (2H, s), 3.53 (4H, m), 3.21 (4H, m), 1.47 (9H, s).

Provenance & Evidence