Trifluoroacetic acid → HCID 68032129, compound

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N-(4-Chloro-5-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-(methylsulfonamido)benzamide was treated with boron tribromide as described in Example 117. The crude product (140 mg) was treated with 0.8 M trifluoroacetic acid in DCM (4.0 mL) at room temperature overnight. Solvent was evaporated in vacuo and the product was purified by preparative HPLC (0.1% TFA MeOH/H2O) to give 53 mg (55% yield) of the title compound. H1-NMR (500 MHz, CD3OD) δ 8.57 (1H, s), 8.36 (1H, s), 7.98 (2H, d, J=8.9 Hz), 7.41 (2H, d, J=8.9 Hz), 3.48-3.53 (4H, m), 3.42-3.48 (4H, m), 3.08 (3H, s).

Provenance & Evidence