HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 68227418, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 54851625 | HCID 54851625 | — |
| Reactant | HCID 66692213 | HCID 66692213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68227418 | HCID 68227418 | 33% |
Reaction Steps
To a solution of N-(4-chloro-2-nitro-5-(piperazin-1-yl)phenyl)-4-(dimethylamino)benzamide, 2 TFA (Preparation D, 35 mg, 0.055 mmol) in DMF (2 ml) was added 3-(2-methoxyphenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (Preparation O, 15.44 mg, 0.066 mmol), HATU (25.3 mg, 0.066 mmol), followed by DIEA (0.048 ml, 0.277 mmol). The reaction was stirred at r.t. for 10 mins. Purified by prep-HPLC to afford 14 mg (33%) of the title compound. HPLC/MS (Method SZ6): (ES+) m/z (M+H)+=618; Rt=2.98 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362004B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-07cc3626a62a4f94b1daa41a41ef509b |
| Source note | uspto-grants-2013_01 |