HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → (4-(5-Amino-2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-(naphthalen-1-yl)isoxazol-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 22273264 | HCID 22273264 | — |
| Reactant | 3-(1-Naphthyl)-5-methylisoxazole-4-carboxylic acid | HCID 64158052 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-(5-Amino-2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-(naphthalen-1-yl)isoxazol-4-yl)methanone | HCID 68032125 | — |
Reaction Steps
A mixture of 3-(1-naphthyl)-5-methylisoxazole-4-carboxylic acid (394 mg, 1.558 mmol), 4-chloro-2-nitro-5-(piperazin-1-yl)aniline (400 mg, 1.558 mmol, prepared as described in [El-Abadelah, M. M.; Nazer, M. Z.; El-Abadla, N. S.; Awadallah, A. M. Asian Journal of Chemistry 1999, 11(4), 1463-1468.]), EDC (448 mg, 2.337 mmol), and DMAP (571 mg, 4.67 mmol) in DCM (5 mL)/DMF (3 mL) was stirred overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362004B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-d8cad55c004542258ecb6e0f672997c2 |
| Source note | uspto-grants-2013_01 |