HCID 66691742, compound → HCID 66691672, compound

HRID 1808891Notes

Reaction equation

HRID 1808891 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([NH:11][C:12](=[O:23])[C:13]2[CH:18]=[CH:17][C:16]([CH2:19][N:20]([CH3:22])[CH3:21])=[CH:15][CH:14]=2)=[CH:4][C:3]=1[N:24]1[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:1][C:2]1[C:3]([N:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)=[CH:4][C:5]([NH:11][C:12](=[O:23])[C:13]2[CH:14]=[CH:15][C:16]([CH2:19][N:20]([CH3:22])[CH3:21])=[CH:17][CH:18]=2)=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1

Participants

3

Reactant 1

HCID 66691742HCID 66691742, compound

Product 1

HCID 66691672HCID 66691672, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

tert-butyl 4-(2-chloro-5-(4-((dimethylamino)methyl)benzamido)-4-nitrophenyl)piperazine-1-carboxylate was stirred in TFA/DCM (50%) for 1 h. After solvent was removed, the residue was dried in vacuo overnight.

Workup

  1. customAfter solvent was removed
  2. customthe residue was dried in vacuo overnight

Sources & evidence

ORD record
ord-fc6175165c4e41438a9dd5c41b122781
Source dataset
uspto-grants-2013_01
Patent number
US08362004B2

Reaction notes

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