Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 66692939, compound

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Reaction Steps

A mixture of 4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazole-5-carboxylic acid (44.7 mg, 0.192 mmol), N-(4-chloro-2-nitro-5-(piperazin-1-yl)phenyl)-4-((dimethylamino)methyl)benzamide (85 mg, 0.160 mmol), HATU (79 mg, 0.208 mmol), and DMAP (78 mg, 0.639 mmol) in NMP (2 mL) was stirred for 3 h. HPLC purification, then silica column purification afforded the title compound (28 mg, 0.041 mmol). 1H-NMR (CDCl3, 500 MHz): δ11.62 (1H, s), 8.57 (1H, s), 8.31 (1H, s), 8.06 (2H, d, J=8.24 Hz), 7.81 (1H, d, J=7.24 Hz), 7.69 (2H, d, J=7.93 Hz), 7.43 (1H, t, J=8.24 Hz), 7.13 (1H, t, J=7.32 Hz), 7.01 (1H, d, J=7.24 Hz), 4.28 (2H, s), 4.20 (2H, s), 3.94 (2H, m), 3.83 (3H, s), 3.25 (4H, s), 2.83 (6H, s), 2.68 (2H, m). HPLC/MS (Method J): (ES+) m/z (M+H)+=633; Rt=1.52 min.

Provenance & Evidence