3-(2-Methoxyphenyl)-5-methyl-1,2-oxazole-4-carboxylic acid → Methyl 2-amino-5-chloro-4-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)benzoate

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3-(2-Methoxyphenyl)-5-methylisoxazole-4-carboxylic acid and methyl 2-amino-5-chloro-4-(piperazin-1-yl)benzoate (TFA salt) were coupled under the conditions described in Preparation M to give methyl 2-amino-5-chloro-4-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)benzoate. 1H-NMR (CDCl3, 400 MHz): δ 7.82 (1H, s), 7.60-7.47 (2H, m), 7.13-6.97 (2H, m), 6.01 (1H, s), 3.85 (3H, s), 3.84 (2H, s), 3.80 (3H, s), 3.25 (2H, s), 2.99 (2H, s), 2.58 (3H, s), 2.42 (2H, s).

Provenance & Evidence