Formaldehyde → HCID 49785429, compound

HRID 1808907Notes

Reaction equation

HRID 1808907 reaction equation
[ClH:1].[N:2]1([C:9]2[CH:10]=[C:11]([NH:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH:28]([F:30])[F:29])(=[O:20])=[O:19])[CH:12]=[CH:13][C:14]=2[O:15][CH3:16])[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:31]=O>[BH4-].[Na+].C(#N)C>[ClH:1].[F:29][CH:28]([F:30])[O:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[S:18]([NH:17][C:11]1[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:9]([N:2]2[CH2:8][CH2:7][CH2:6][N:5]([CH3:31])[CH2:4][CH2:3]2)[CH:10]=1)(=[O:20])=[O:19]

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 49785427HCID 49785427, compound

Product 1

HCID 49785429HCID 49785429, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 4311764Sodium borohydrideSolvent

Procedure

The title compound was prepared from the title compound of Example 3 under reductive amination conditions employing an aqueous solution of formaldehyde and sodium borohydride in acetonitrile as solvent.

Sources & evidence

ORD record
ord-c77ab328f79249938b660ba1ea49ea6c
Source dataset
uspto-grants-2013_01
Patent number
US08362010B2

Reaction notes

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