1-Benzyl 4-tert-butyl 5,6-dimethyl-1,4-diazepane-1,4-dicarboxylate → Tert-butyl 6,7-dimethyl-1,4-diazepane-1-carboxylate

Participants

Reaction Steps

To a solution of 1-3 (3.3 g, 9.1 mmol) in ethyl acetate (45 mL) was added 20% palladium hydroxide on carbon (256 mg) and the reaction was stirred at room temperature under balloon pressure of hydrogen gas overnight. The reaction was filtered through celite and concentrated in vacuo to afford 1-4.

Provenance & Evidence