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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18090Generated: October 26, 2026

tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate → (S)-2-(1,8-Naphthyridin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl ester

https://huagongshe.com/reaction/18090

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylateHCID 1502020—
Reactant2-Chloro-1,8-naphthyridineHCID 5152838—
Product(S)-2-(1,8-Naphthyridin-2-ylamino)methyl-piperidine-1-carboxylic acid tert butyl esterHCID 8662601270.8%

Reaction Steps

The title compound (0.28 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (0.35 g) and 2-chloro-1,8-naphthyridine (0.19 g) according to the method of D30.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741329B2
Source datasetuspto-grants-2010_06
ORD IDord-f81a3654b4404a418e11bbcfcd345352
Source noteuspto-grants-2010_06