HCID 59542515, compound → HCID 59542565, compound

Participants

Reaction Conditions

Reaction Steps

5-(2,2,2-Trifluoro-ethyl)-thiophene-3-carboxylic acid ethyl ester (1.24 g, 5.2 mmol) was dissolved in IMS (10 mL) and aqueous sodium hydroxide (1 M, 10 mL) was added. The reaction was heated to 140° C. using microwave irradiation for 20 minutes and then partitioned between water and DCM. The aqueous solution was separated, acidified with 1 N hydrochloric acid and then extracted with DCM. The organic solution was dried over magnesium sulphate, filtered and the solvent removed. The resulting oil was triturated with cyclohexane and minimal diethyl ether to give the title compound (0.22 g). 1H NMR (400 MHz, CHCl3-d): δ 8.2 (s, 1H), 7.5 (s, 1H), 3.6 (q, 2H).

Provenance & Evidence