Tert-Butyl nitrite → HCID 59542572, compound

Participants

Reaction Steps

4-(5-Amino-4-ethoxycarbonyl-thiophen-2-yl)-piperidine-1-carboxylic acid benzyl ester (1.46 g, 3.76 mmol) was added to t-butyl nitrite (5.64 mmol) and copper(II)chloride (3.76 mmol) in IMS (40 mL). The reaction was stirred for 1.5 hours then saturated aqueous ammonium chloride (7 mL) was added and the resulting mixture stirred for a further 15 minutes. The solvent was removed under vacuum and product partitioned between ethyl acetate and water. The organic layer was dried over magnesium sulphate, filtered and the solvent removed to give the title compound (1.17 g). LCMS m/z 374 [M+H]+ RT=4.18 min (Analytical Method 4).

Provenance & Evidence