反应详情

To a solution of (4-bromo-thiophen-2-yl)-methanol (13.2 g, 72 mmol) in DCM (140 mL) was added t-butyldimethylsilyl chloride (79.2 mmol) and imidazole (79.2 mmol). The reaction was stirred for 1 hour, then quenched with 1 M HCl and extracted into DCM. The organic solution was dried over magnesium sulphate, filtered and the solvent removed to give the title compound as a yellow oil, which was used without further purification.

1. customquenched with 1 M HCl
2. extractionextracted into DCM
3. dry with materialThe organic solution was dried over magnesium sulphate
4. filtrationfiltered
5. customthe solvent removed