HCID 59542474, compound → HCID 59542542, compound

Participants

Reaction Steps

3-[4-(Azepane-1-carbonyl)-thiophen-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (0.066 g) was dissolved in TFA/DCM (1:1, 5 mL) and stirred for 1 hour. The solvent was then evaporated and the residue dissolved in DCM and purified using a SCX-2 column. After washing with methanol and acetonitrile, the desired compound was washed from the column with ammonia (2 M in MeOH). Evaporation gave the title compound as a clear colourless oil (0.052 g). LCMS m/z 293.14 [M+H]+ RT=5.27min (Analytical Method 2). 1H NMR δ (ppm)(CHCl3-d): 7.3 (s, 1H), 6.9 (s, 1H), 3.8 (m, 2H), 3.5 (m, 2H), 3.3 (d, 1H), 3.1 (d, 1H), 2.9 (m, 1H), 2.7-2.6 (m, 3H), 2.1 (m, 1H), 1.8-1.5 (m, 11H).

Provenance & Evidence