Trifluoroacetic acid → (5-Piperidin-4-yl-thiophen-3-yl)-(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]oct-6-yl)-methanone

Participants

Reaction Steps

4-[4-(1,3,3-Trimethyl-6-aza-bicyclo[3.2.1]octane-6-carbonyl)-thiophen-2-yl]-piperidine-1 carboxylic acid tert-butyl ester [Enantiomer E] (0.06 g) was dissolved in DCM (2 mL) and TFA (1 mL) and the reaction stirred at room temperature for 2 hours. The solvent was evaporated and the residue product was purified by flash chromatography on a SCX-2 cartridge, washing with acetonitrile and then eluting with 2 M ammonia in methanol. The fractions containing the desired product were concentrated under vacuum to give the title compound (0.038 g). LCMS m/z 347.17 [M+H]+ RT=6.63 min (Analytical Method 2).

Provenance & Evidence