Acetic Anhydride → HCID 86761758, compound

Participants

Reaction Steps

cis-(Octahydro-quinolin-1-yl)-(5-pyrrolidin-3-yl-thiophen-3-yl)-methanone (CC-177) (0.065 g, 0.19 mmol) was dissolved in triethylamine (2 mL) and acetic anhydride was added and the resulting mixture stirred for 20 minutes. The solvent was evaporated and the resulting gum was purified by HPLC eluting with 10%-98% acetonitrile in water (0.1% formic acid). The fractions containing the desired product were concentrated under vacuum to give the title compound (0.029 g). LCMS m/z 361.20[M+H]+ RT=9.24 min (Analytical Method 2).

Provenance & Evidence