2,3-Dichloropyridine → HCID 67094899, compound

HRID 1809126Notes

Reaction equation

HRID 1809126 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]3[C:16]4[O:17][CH2:18][CH2:19][NH:20][C:15]=4[CH:14]=[CH:13][CH:12]=3)[NH:8][C:7]=2[CH:21]=1.[Br:24][C:25]1[CH:26]=[CH:27][C:28](Cl)=[N:29][CH:30]=1.ClC1C(Cl)=CC=CN=1>>[Br:24][C:25]1[CH:26]=[CH:27][C:28]([N:20]2[C:15]3[CH:14]=[CH:13][CH:12]=[C:11]([C:9]4[NH:8][C:7]5[CH:21]=[C:3]([C:2]([F:22])([F:1])[F:23])[CH:4]=[CH:5][C:6]=5[N:10]=4)[C:16]=3[O:17][CH2:18][CH2:19]2)=[N:29][CH:30]=1

Participants

4

Reactant 3

HCID 169882,3-DichloropyridineHCID 27344145-Bromo-2-chloropyridineHCID 67094559HCID 67094559, compound

Product 1

HCID 67094899HCID 67094899, compoundYield 91%

Procedure

The procedure of Example 6 was repeated except for using 8-(6-(trifloromethyl)-1H-benzo[d]imidazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine and 5-bromo-2-chloropyridine instead of 4-(5-tert-butyl-1H-benzo[d]imidazol-2-yl)benzenamine and 2,3-dichloropyridine in Example 6 respectively to obtain the title compound (4.3 g, yield: 91%).

Sources & evidence

ORD record
ord-ec04ffd27d1b4f3688f92fad048071ab
Source dataset
uspto-grants-2013_01
Patent number
US08362012B2

Reaction notes

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