Methanol → HCID 18364941, compound

HRID 1809132Notes

Reaction equation

HRID 1809132 reaction equation
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[OH:13].[H][H].[CH3:17]O>[Pd]>[CH3:17][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:2])=[O:14])=[C:5]([OH:13])[C:6]=1[NH2:10]

Participants

5

Reactant 3

HCID 887MethanolHCID 596904Methyl 2-hydroxy-3-nitrobenzoateHCID 178418361HCID 178418361, compound

Product 1

HCID 18364941HCID 18364941, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

10 g (51 mmol) of 2-hydroxy-3-nitrobenzoic acid methyl ester was dissolved in 100 mL of methanol, 1.0 g of 5% Pd/C was added thereto, hydrogen gas was filled and stirred at room temperature for 24 hr. The reaction mixture was filtered through diatomite to remove the catalyst, followed by concentration under reduced pressure to obtain the title compound (8.4 g, yield: 99%).

Workup

  1. filtrationThe reaction mixture was filtered through diatomite
  2. customto remove the catalyst
  3. concentrationfollowed by concentration under reduced pressure

Sources & evidence

ORD record
ord-8135af6918dc40e190fbda6e1513955d
Source dataset
uspto-grants-2013_01
Patent number
US08362012B2

Reaction notes

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