2-Bromo-3-(2-methoxyvinyl)pyridine → 2-(2-Bromopyridin-3-yl)acetaldehyde

Participants

Reaction Conditions

Reaction Steps

A solution of E and Z mixture of 2-bromo-3-(2-methoxyvinyl)pyridine (1.88 g, 8.79 mmol) in formic acid (96%, 10 mL) was stirred at 60° C. for 16 hours and at 80° C. for 3 hours before cooled to room temperature. Most of formic acid was removed. The mixture was diluted with ethyl acetate, washed with sodium bicarbonate and brine, dried over magnesium sulfate and concentrated. Purification by chromatography on silica gel gave 2-(2-bromopyridin-3-yl)acetaldehyde (864 mg, 53% yield) as yellow solid.

Provenance & Evidence