反应详情

To a 100 mL recovery flask was added 4-(2-hydroxytetrazol-1-yl)-1-benzyloxybenzene 52 (515 mg, 1.92 mmol, 1.0 eq.) and CH3OH (20 mL). The solution was purged with N2 upon which 10% Pd/C (50 mg) was added. The flask was sealed and fitted with a balloon filled with H2. The reaction was stirred overnight at room temperature. The reaction was filtered through a pad of Celite and concentrated to give an off-white solid which was used in subsequent reactions without further purification (300 mg, 93%).

1. customThe solution was purged with N2 upon which 10% Pd/C (50 mg)
2. additionwas added
3. customThe flask was sealed
4. customfitted with a balloon
5. additionfilled with H2
6. filtrationThe reaction was filtered through a pad of Celite
7. concentrationconcentrated
8. customto give an off-white solid which
9. customwas used in subsequent reactions without further purification (300 mg, 93%)