Lithium Hydroxide → HCID 25206017, compound

Participants

Reaction Steps

To a solution of 4-{[3-(3,4-Dimethoxy-phenyl)-imidazo[1,2-a]pyrazin-8-ylamino]-methyl}-benzoic acid methyl ester (0.20 g, 0.48 mmol) in tetrahydrofuran (4 ml) was added lithium hydroxide (0.72 ml, 0.72 mmol, 1 M aqueous solution). The reaction was stirred at ambient temperature for 24 hours then diluted with water (30 mL) and washed with ethyl acetate (30 ml). The aqueous phase was acidified with 1 M aqueous HCl and extracted with ethyl acetate (3×30 ml), the organic layers were combined and dried with magnesium sulphate, filtered and concentrated in vaccuo. The product, 4-{[3-(3,4-Dimethoxy-phenyl)-imidazo[1,2-a]pyrazin-8-ylamino]-methyl}-benzoic acid, is obtained as an off white solid (50 mg, 26%) (LC-MS m/z 405 [M+H]+).

Provenance & Evidence