N-bromobutanimide → HCID 58337123, compound

HRID 1809180Notes

Reaction equation

HRID 1809180 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][N:7]=1.[Br:12]N1C(=O)CCC1=O>C(Cl)Cl>[Br:12][C:8]1[N:4]2[CH:5]=[CH:6][N:7]=[C:2]([Cl:1])[C:3]2=[N:10][C:9]=1[CH3:11]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 133890828-Chloro-2-methylimidazo[1,2-a]pyrazine

Product 1

HCID 58337123HCID 58337123, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 8-Chloro-2-methyl-imidazo[1,2-a]pyrazine (0.7 g, 4.18 mmol) in DCM (20 ml) is added N-bromosuccinimide (0.74 g, 4.18 mmol) and the reaction stirred at room temperature for 2 h. After this time the solution is washed with saturated aqueous solution of Na2CO3 (2×20 ml), dried (MgSO4), filtered and concentrated in vacuo to give 3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine (0.771 g, 75%).

Workup

  1. washAfter this time the solution is washed with saturated aqueous solution of Na2CO3 (2×20 ml)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f6c50ad207514c98887b56f6731dbc8a
Source dataset
uspto-grants-2013_01
Patent number
US08362018B2

Reaction notes

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