Hydrochloric Acid → HCID 178430717, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of KOH (6 g, 154 mmol) in water (46 mL) at 5° C. is added slowly bromine followed by 3-hydroxy-6-methyl-pyrazine-2-carboxylic acid amide (2.6 g, 17.0 mmol) with rapid stirring. The reaction mixture is warmed to 85° C. and stirred for 1 h 30 min. The reaction is cooled to 20° C. and acidified with HCl conc, basified with ammonium hydroxide conc. and left stand overnight at r.t. The solid obtained is filtered and washed with cold water, dried with air and then dried further in a vacuum oven at 60° C. to give 3-amino-5-methyl-pyrazin-2-ol as a beige solid (1.63 g, 76%).

Provenance & Evidence