N-bromobutanimide → HCID 58337160, compound

Participants

Reaction Steps

N-bromosuccinimide (348 mg, 1.96 mmol) is added to a solution of 8-chloro-5-methyl-imidazo[1,2-a]pyrazine (327 mg, 1.98 mmol) in DCM (6 mL) and the reaction stirred at room temperature for 2 h. Once the reaction is finished the reaction mixture is diluted with DCM and washed twice with 4 mL of Na2CO3 sat., dried (MgSO4), filtered and concentrated in vacuo to give a crude mixture that is purified by column chromatography using a gradient of (Pet.Ether40-60/AcOEt: 9/1 to 7/3) to give 3-Bromo-8-chloro-5-methyl-imidazo[1,2-a]pyrazine as a brown solid (335 mg, 69%).

Provenance & Evidence