Imidazole → 8-Hydroxy-6-methylimidazo[1,2-a]pyrazine

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,6-dimethyl-8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-1-ium bromide salt (4.3 g, 16.4 mmol) and imidazole (20.4 g, 310 mmol) is stirred at 175° C. for 20 h. After this time the reaction mixture is cooled down to 100° C. and poured into ice-water with vigorous stirring. No precipitation is observed therefore the solvent is removed and the imidazole distilled off under vacuum at approx. 130° C. The solid remaining is triturated with DCM to give 6-methyl-7H-imidazo[1,2-a]pyrazin-8-one as a brown solid (970 mg). The mother liq. are purified by column chromatography using a gradient of (DMC/MeOH:99/1 to 95/5) to give a further 667 mg of 6-methyl-7H-imidazo[1,2-a]pyrazin-8-one as a pale yellow solid (1.66 g, 68%).

Provenance & Evidence