Potassium Hydroxide → HCID 43119857, compound

HRID 1809334Notes

Reaction equation

HRID 1809334 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16](C=O)[CH2:15][CH2:14][CH2:13]2)(=[O:9])=[O:8].[OH-].[K+]>CCO>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[NH:16][CH2:15][CH2:14][CH2:13]2)(=[O:9])=[O:8]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 59432926HCID 59432926, compound

Product 1

HCID 43119857HCID 43119857, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-Formyl-1,2,3,4-tetrahydroquinoline-6-sulfonic acid thiazol-2-ylamide (0.50 g, 1.6 mmol) and KOH (0.75 g, 13.4 mmol) in EtOH (5.0 mL) was stirred at room temperature for 1 h. The formed precipitate was filtered and washed with 1:1-EtOH:ET2O to obtain the desired amine (480 mg, 1.6 mmol, 100% yield) as a white solid. LC/MS (10-99%) M/Z: M+1 obs=296.3; tR=1.90 min.

Workup

  1. filtrationThe formed precipitate was filtered
  2. washwashed with 1

Sources & evidence

ORD record
ord-003339cdf54f478f8684db4ab63ebd47
Source dataset
uspto-grants-2013_01
Patent number
US08362032B2

Reaction notes

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