反应详情

To a solution of 5.0 g (29.4 mmol) of 2-fluoro-4-methoxybenzoic acid in methanol (50 mL) at room temperature are added 2.13 mL (29.4 mmol) of thionyl chloride. The reaction is stirred at room temperature for 16 h and the solvent is removed under reduced pressure. The residue is dissolved in DCM and washed with brine. The organic layer is dried (MgSO4), filtered and the filtrate is concentrated under reduced pressure to give 5.04 g (27.1 mmol) of 2-fluoro-4-methoxybenzoic acid methyl ester. Yield: 92%, ES-MS: m/z 185 [M+H].

1. customthe solvent is removed under reduced pressure
2. dissolutionThe residue is dissolved in DCM
3. washwashed with brine
4. dry with materialThe organic layer is dried (MgSO4)
5. filtrationfiltered
6. concentrationthe filtrate is concentrated under reduced pressure