Dimethylamine, hydrochloride → HCID 68634168, compound

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Reaction Steps

To a solution of (B3) in DCE (0.1 M) was added Me2NH.HCl (8 eq.) and Ti(iPrO)4 (2.0 eq.) and the mixture stirred at RT for 12 h. To this solution, NaBH3CN (1.1 eq.) was added and stirring was continued for 12 h. The reaction mixture was quenched by the addition of sat. aq. NaHCO3, then, the aqueous phase was separated and extracted several times with DCM. The combined organic extracts were washed with brine and dried (Na2SO4). Evaporation of the solvent gave a residue of 4-(2,4-dimethoxybenzyl)-2-{4-[(methylamino)methyl]phenyl}-3,4-dihydro-5H-1,4,8b-triazaacenaphthylen-5-one which was used in the next step without further purification. MS (ES+) C26H26N4O3 requires: 442, found: 443 (M+H)+.

Provenance & Evidence