Methyl iodide → HCID 68632375, compound

Participants

Reaction Steps

Cs2CO3 (1.2 eq.) was added to a solution of (C6) in dry DMF (0.2 M). The resulting white suspension was stirred at RT for 30 min. After cooling down to 0° C., iodomethane (7 eq.) was added, then, the reaction mixture was stirred at RT for 90 min. The solution was diluted with EtOAc and washed with brine (2×) and dried (Na2SO4). Evaporation of the solvent afforded the title compound that was used in the next step without further purification. 1H NMR (300 MHz, CDCl3, 300K) δ 9.02 (1H, s), 8.14 (2H, d, J=8.7 Hz), 8.01-7.95 (2H, m), 7.85 (2H, d, J=8.5 Hz), 7.42 (1H, t, J=7.4 Hz), 4.02 (3H, s). MS (ES+) C16H11N3O2 required: 277, found: 278 (M+H)+.

Provenance & Evidence