HCID 58674965, compound → HCID 58674957, compound

Participants

Reaction Steps

To a solution of (S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenyl-propionic acid tert-butyl ester (4 g, 8.92 mmol) in a mixture of MeOH (40 mL) and EtOAc (10 mL) was added 10% Pd/C (500 mg). The mixture was degassed and stirred at room temperature for 4 hours under an atmosphere of hydrogen (balloon pressure). The reaction mixture was filtered through a short pad of celite which was then flushed with MeOH. The combined filtrates were evaporated under reduced pressure to afford the title compound as a white solid (2.6 g, 92%); 1H NMR (400 MHz, CDCl3) δ 1.48 (9H, s), 3.32 (1H, dd), 3.52 (1H, dd), 3.95 (2H, br s), 5.55 (1H, dd), 6.00 (1H, t), 6.55 (1H, d), 6.72 (1H, d), 7.18-7.35 (5H, m).

Provenance & Evidence