5-Bromosalicylic acid → 5-Cyano-2-isopropoxybenzoic acid

HRID 1809517Notes

Reaction equation

HRID 1809517 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10](OC(C)C)[CH:11]=1)[C:6]([OH:8])=[O:7])#[N:2].BrC1C=[CH:19][C:20]([OH:26])=[C:21](C=1)C(O)=O>>[C:1]([C:3]1[CH:11]=[CH:10][C:9]([O:26][CH:20]([CH3:21])[CH3:19])=[C:5]([CH:4]=1)[C:6]([OH:8])=[O:7])#[N:2]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 671962143-Cyano-5-isopropoxybenzoic acid

Product 1

HCID 211002975-Cyano-2-isopropoxybenzoic acid

Procedure

Prepared in an analogous fashion to 3-cyano-5-isopropoxybenzoic acid starting from 5-bromo-2-hydroxybenzoic acid. LCMS-ESI (m/z) calculated for C11H11NO3: 205.2; found 206.1 [M+H]+, tR=2.70 min.

Sources & evidence

ORD record
ord-655d40f0fa684d1a8849abc2628cd3b7
Source dataset
uspto-grants-2013_01
Patent number
US08362048B2

Reaction notes

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