3-Bromo-5-(trifluoromethoxy)benzoic acid → 3-Bromo-5-trifluoromethoxybenzoic acid methylester

HRID 1809523Notes

Reaction equation

HRID 1809523 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][C:12]([F:15])([F:14])[F:13])[CH:10]=1)[C:5]([OH:7])=[O:6].Br[C:17]1C=C(C=C(O)C=1)C(OC)=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][C:12]([F:13])([F:14])[F:15])[CH:10]=1)[C:5]([O:7][CH3:17])=[O:6]

Participants

3

Reactant 2

HCID 27828433-Bromo-5-(trifluoromethoxy)benzoic acidHCID 53216607Methyl 3-bromo-5-hydroxybenzoate

Product 1

HCID 534196213-Bromo-5-trifluoromethoxybenzoic acid methylester

Procedure

Prepared from 3-bromo-5-(trifluoromethoxy)benzoic acid according to the procedure for methyl 3-bromo-5-hydroxybenzoate. LCMS-ESI (m/z) calculated for C9H6BrF3O3: 299.0; no m/z observed, tR=4.08 min. 1H NMR (400 MHz, CDCl3) δ 8.12 (dd, J=3.9, 2.4 Hz, 1H), 7.83 (dt, J=2.2, 1.2 Hz, 1H), 7.57 (ddd, J=2.4, 1.8, 0.9 Hz, 1H), 3.99-3.87 (m, 3H).

Sources & evidence

ORD record
ord-bc1de24079914167970aeabe36667a4e
Source dataset
uspto-grants-2013_01
Patent number
US08362048B2

Reaction notes

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