HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl isothiocyanate → 1-Benzoyl-3-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl isothiocyanate | HCID 68284 | — |
| Reactant | 5-Bromo-3-(phenylthio)pyridin-2-amine | HCID 45926064 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzoyl-3-(5-bromo-3-(phenylthio)pyridin-2-yl)thiourea | HCID 86631487 | 95.7% |
Reaction Steps
5-Bromo-3-(phenylthio)pyridin-2-amine (17 g, 60.5 mmol), benzoyl isothiocyanate (9.79 mL, 72.6 mmol), and THF (300 mL) were stirred at 40° C. overnight. The THF was concentrated to ˜1/2 volume and 9:1 hexanes:EtOAc (500 mL) added and precipitate filtered to afford the title compound (25.7 g, 95.7% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362037B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-6a7b047ae9534c1797cea17951cef04c |
| Source note | uspto-grants-2013_01 |