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Dimethylformamide → Tert-butyl 4-(chloro(hydroxyimino)methyl)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | Tert-butyl 4-((hydroxyimino)methyl)piperidine-1-carboxylate | HCID 72698249 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | Tert-butyl 4-(chloro(hydroxyimino)methyl)piperidine-1-carboxylate | HCID 76573117 | 100% |
反応手順
A 250 mL flask was charged with tert-butyl 4-((hydroxyimino)methyl)piperidine-1-carboxylate (2.0 g, 8.8 mmol) and DMF (100 mL). 1-chloropyrrolidine-2,5-dione (1.2 g, 8.8 mmol) was added and stirred at ambient temperature overnight. The reaction was poured into 1:1 brine:water and extracted with EtOAc. The organic layer was washed twice with water, dried over sodium sulfate, filtered and concentrated to afford tert-butyl 4-(chloro(hydroxyimino)methyl)piperidine-1-carboxylate (2.3 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08362037B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-e30fc72fc48a4cea800efdb408739fa7 |
| 出典メモ | uspto-grants-2013_01 |