Hydrochloric Acid → HCID 67487241, compound

Participants

Reaction Steps

tert-butyl 4-(5-(3-phenoxy-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidine-1-carboxylate (10 g, 16 mmol) was dissolved in 1:1 CH2Cl2:methanol and 4N HCl in dioxane was added (80 mL). The reaction was stirred for 1 hour and then concentrated in vacuo to afford 3-phenoxy-N-(3-(piperidin-4-yl)-1,2,4-thiadiazol-5-yl)-5-(thieno[3,2-b]pyridin-7-ylthio)pyridin-2-amine trihydrochloride (10 g, 100%).

Provenance & Evidence