反应详情

Tert-butyl 4-(5-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)piperidine-1-carboxylate (0.587 g, 1.04 mmol) was dissolved in 1:1 CH2Cl2/methanol and 4N HCl in dioxane was added and stirred at ambient temperature for 1 hour. The reaction was concentrated and dried in vacuum oven. The HCl salt was partitioned between 5% MeOH in CH2Cl2 and saturated aqueous sodium bicarbonate. The organic layer was separated, dried over sodium sulfate, filtered and concentrated to give N-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)-3-(piperidin-4-yl)-1,2,4-thiadiazol-5-amine (0.473 g, 98.0% yield).

1. additionwas added
2. concentrationThe reaction was concentrated
3. customdried in vacuum oven
4. customThe HCl salt was partitioned between 5% MeOH in CH2Cl2 and saturated aqueous sodium bicarbonate
5. customThe organic layer was separated
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated