Hydrochloric Acid → HCID 86641093, compound

Participants

Reaction Steps

A 25 mL flask was charged with tert-butyl 3-methyl-4-(2-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate (0.296 g, 0.514 mmol), CH2Cl2 (3 mL) and MeOH (3 mL). 4N HCl in dioxane (6 mL) was added and the reaction was stirred for 1 hour and then concentrated. The crude material was dissolved in CH2Cl2 and washed with saturated aqueous sodium bicarbonate. The organic layer was dried over sodium sulfate, filtered and concentrated to afford N-(4-(3-methylpiperidin-4-yl)thiazol-2-yl)-3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-amine (0.202 g, 82% yield)

Provenance & Evidence