Hydrochloric Acid → HCID 66994968, compound

Participants

Reaction Steps

A 250 mL flask was charged with tert-butyl 3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylcarbamate (9.1 g, 17 mmol) and 1:1 mixture of CH2Cl2 and MeOH (100 mL). 4N HCl in dioxane was added (50 mL) and the reaction was stirred at ambient temperature overnight. The solvent was removed and dried on high vacuum to afford 3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-amine (8.0 g, 109% yield) as a yellow solid.

Provenance & Evidence