Water → HCID 86641100, compound

Participants

Reaction Steps

3-Phenoxy-N-(4-(piperidin-4-yl)thiazol-2-yl)-5-(pyridin-2-ylthio)pyridin-2-amine (0.075 g, 0.162 mmol) and N-(tert-butoxycarbonyl)-N-[4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl]azanide (0.0490 g, 0.162 mmol) were dissolved in dichloromethane (2 mL) and stirred at ambient temperature for 18 hours. Water was added and the reaction mixture was extracted with dichloromethane. The organic layer was dried, filtered and concentrated. The crude material was purified by silica gel chromatography (25-50% ethyl acetate in hexanes) provided tert-butyl 4(2-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-ylamino)thiazol-4-yl)piperidin-1-ylsulfonylcarbamate (0.0785 g, 75.4% yield).

Provenance & Evidence