4-chloro-N-(2-(dimethylamino)ethyl)picolinamide → 4-(6-(4-(1-acetylpiperidin-4-yl)thiazol-2-ylamino)-5-phenoxypyridin-3-ylthio)-N-(2-(dimethylamino)ethyl)picolinamide

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Reaction Steps

Prepared from methyl 3-(6-(4-(1-acetylpiperidin-4-yl)thiazol-2-ylamino)-5-phenoxypyridin-3-ylthio)propanoate and 4-chloro-N-(2-(dimethylamino)ethyl)picolinamide as described in Example 3, Step C. 1H NMR (CDCl3) δ 1.62-1.70 (m, 2H), 2.07-2.12 (m, 2H), 2.11 (s, 3H), 2.28 (s, 6H), 2.51 (t, 2H), 2.71 (t, 1H), 2.88 (tt, 1H), 3.19 (t, 1H), 3.52 (dd, 2H), 3.90 (d, 1H), 4.71 (d, 1H), 6.51 (s, 1H), 7.00 (dd, 1H), 7.09-7.15 (m, 3H), 7.21 (t, 1H), 7.40 (t, 2H), 7.80 (d, 1H), 8.22 (bs, 1H), 8.24 (d, 1H), 8.28 (d, 1H), 8.84 (bs, 1H).

Provenance & Evidence