Methyl Thioglycolate → HCID 68705417, compound

Participants

Reaction Steps

Following the procedure in Example 52, tert-butyl 3-(5-(5-bromo-3-(2-methylpyridin-3-yloxy)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate (526 mg, 0.917 mmol) and methyl 2-mercaptoacetate (92.3 μL, 1.01 mmol) afforded tert-butyl 3-(5-(5-(2-methoxy-2-oxoethylthio)-3-(2-methylpyridin-3-yloxy)pyridin-2-ylamino)-1,2,4-thiadiazol-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate (461 mg, 0.770 mmol, 83.9% yield).

Provenance & Evidence